Correction: Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

Hepatocyte Nucear Factor (hnf)-4α Induces Transdifferentiation of Hematopoietic Cells into Hepatocytes

Satish Khurana, Amit K Jaiswal and Asok Mukhopadhyay Stem Cell Biology Laboratory From National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi-110067, India. Current address: Stem Cell Institute, Katholieke University, Leuven, Belgium. Running head: HNF4α in hepatic differentiation Address correspondence to: Asok Mukhopadhyay, Ph.D., Stem Cell Biology Laboratory, National Institute of ...

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

HNF-4alpha is a transcription factor of the nuclear hormone receptor family that is expressed in the hepatic diverticulum at the onset of liver development. Mouse embryos lacking HNF-4alpha fail to complete gastrulation due to dysfunction of the visceral endoderm. This early embryonic lethality has so far prevented any analyses of the contribution of HNF-4alpha toward liver development and hepa...

Hepatocyte Nuclear Factor-4α Mediates Redox Sensitivity of Inducible Nitric Oxide Synthase Gene Transcription Running Title: HNF-4α, PC4 and Redox Regulation of iNOS Expression

Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose.

Transcription factor carbohydrate responsive element binding protein (ChREBP) promotes glycolysis and lipogenesis in metabolic tissues and cancer cells. ChREBP-α and ChREBP-β, two isoforms of ChREBP transcribed from different promoters, are both transcriptionally induced by glucose. However, the mechanism by which glucose increases ChREBP mRNA levels remains unclear. Here we report that hepatoc...

HNF-4α promotes multidrug resistance of gastric cancer cells through the modulation of cell apoptosis

Multidrug resistance (MDR) typically leads to treatment failure, and is associated with disease progression of gastric cancer (GC). In the present study, a total of 15 aberrantly activated transcription factors (TFs) were detected in chemo-resistant GC cells using a TF Activation Profiling Plate Array. Among these TFs, hepatocyte nuclear factor (HNF)-4α was significantly upregulated in multidru...